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KMID : 0356620070220060419
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Journal of Korean Society of Endocrinology
2007 Volume.22 No. 6 p.419 ~ p.427
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The Clinical Significance of Retinoic Acid Receptor β Expressions in Primary and Recurred Metastatic Lymph Node Papillary Thyroid Carcinomas
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Han Jae-Pil
Lee Seong-Jin
Choi Kyung-Chan
Park Young-Euy
Lee Hae-Ri
Kang Jun-Goo
Ryu Ohk-Hyun
Kim Chul-Sik
Lee Byung-Wan
Hong Eun-Gyoung
Kim Hyeon-Kyu
Kim Doo-Man
Yoo Jae-Myung
Ihm Sung-Hee
Yoo Hyung-Joon
Choi Moon-Gi
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Abstract
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Background: The present study was designed to investigate the correlations of retinoic acid receptor β (RARβ) expression for primary and recurred metastatic lymph node (LN) papillary thyroid carcinoma (PTC) tissues and the correlations of RARβ expression with the uptake of I131 as detected on a whole body scan (WBS).
Methods: Primary and metastatic LN PTC tissues were examined by immunohistochemical methods. Staining positivity was calculated, and staining intensity was graded as negative (0), weak (1+), moderate (2+) and strong (3+). Nuclear staining intensity (NSI) of cells from tissues was also examined.
Results: Seventeen patients who had regional cervical LN metastasis without distant metastasis were included in the study, and 13 patients had the abnormal uptake of I131 as detected on a WBS. In primary PTC tissues, RARβ staining positivity and intensity of carcinoma cells were significantly higher than those of normal cells but NSI was significantly higher in normal cells than carcinoma cells. Between primary and metastatic LN PTC tissues, RARβ staining intensity was correlated after controlling for age. Primary PTC tissues from 14 (82.4%) out of 17 patients were concordant between NSI and the uptake of I131 as detected on a WBS. NSI predicted the I131 uptake as detected on a WBS with 81.3% positive predicted value (PPV) and 100% negative predicted value. Metastatic LN PTC tissues from 13 (76.5%) out of 17 patients were concordant between NSI and the uptake of I131 as detected on a WBS. NSI predicted the uptake of I131 as detected on a WBS with 76.5% PPV. When the results of NSI taken either as positive or negative were correlated with those of the uptake of I131 as detected on a WBS in primary and metastatic LN PTC tissues, the correlation was not significant after controlling for age.
Conclusion: Our results demonstrate that nuclear RARβ expression may be decreased in PTC tissues than normal thyroid tissues, and RARβ expression in primary PTC tissues as well as in recurred metastatic LN PTC tissues may predict the uptake of I131 as detected on a WBS. (J Kor Endocr Soc 22:419~427, 2007)
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KEYWORD
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papillary thyroid carcinoma, RAR β, whole body scan
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